| Pair Name | Vitamin C, Methotrexate | ||
| Phytochemical Name | Vitamin C (PubChem CID: 54670067 ) | ||
| Anticancer drug Name | Methotrexate (PubChem CID: 126941 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Vitamin C, Methotrexate | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Phosphorylation | MAPK14 | hsa1432 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Combined low-dose vitamin C and MTX had synergistic anti-proliferative/cytotoxic effects on TNBC cells. In addition, co-treatment increased H2O2 levels and activated both caspase-3 and p38 cell death pathways. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined treatment with vitamin C and methotrexate inhibits triple-negative breast cancer cell growth by increasing H2O2 accumulation and activating caspase-3 and p38 pathways. Oncol Rep. 2017 Apr;37(4):2177-2184. doi: 10.3892/or.2017.5439. | Click |
